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1

Electrochemistry and bioactivity relationship of 6-substituted-4H-Pyrido[4,3,2-kl]acridin-4-one antitumor drug candidates

Bouffier, Laurent, Gosse, Isabelle, Demeunynck, Martine, Mailley, Pascal

Journal:

Bioelectrochemistry

Year:

2012

Language:

english

File:

PDF, 416 KB

english, 2012

2

Abasic DNA structure, reactivity, and recognition

Jean Lhomme, Jean-François Constant, Martine Demeunynck

Journal:

Year:

1999

Language:

english

File:

PDF, 417 KB

english, 1999

3

Synthese von 3,9,15,19,21,23-Hexaazakekulen

Arnaud Tatibouéut, Richard Hancock, Dr. Martine Demeunynck, Jean Lhomme

Journal:

Angewandte Chemie

Year:

1997

Language:

german

File:

PDF, 388 KB

german, 1997

4

Synthesis of 3,9,15,19,21,23-Hexaazakekulene

Arnaud Tatibouët, Richard Hancock, Dr. Martine Demeunynck, Jean Lhomme

Journal:

Angewandte Chemie International Edition

Year:

1997

Language:

english

File:

PDF, 263 KB

english, 1997

5

ChemInform Abstract: Synthesis and Study of an Acridine Substituted Troeger′s Base: Preferential Binding of the (-)-Isomer to B-DNA.

Arnaud Tatibouet, Martine Demeunynck, Chantal Andraud, Andre Collet, Jean Lhomme

Journal:

Year:

1999

File:

PDF, 28 KB

1999

6

ChemInform Abstract: Synthesis of an Imidazo[1,2-e]purine-acridine Heterodimer for Targeting Abasic Sites in DNA

Philippe Belmont, Karine Alarcon, Martine Demeunynck, Jean Lhomme

Journal:

Year:

1999

File:

PDF, 30 KB

1999

7

ChemInform Abstract: Synthesis and Study of a New Adenine—Acridine Tandem, Inhibitor of Exonuclease III.

Philippe Belmont, Martine Demeunynck, Jean-Francois Constant, Jean Lhomme

Journal:

Year:

2000

File:

PDF, 34 KB

2000

8

ChemInform Abstract: N-Methyl-3,4-dihydro-[3,1]oxazinoacridine, a Useful Intermediate in the Synthesis of Polysubstituted Acridines.

Franck Charmantray, Martine Demeunynck, Abderrahim Wardani, Jean Lhomme

Journal:

Year:

2001

File:

PDF, 32 KB

2001

9

ChemInform Abstract: Nucleic Acid Conformation Diversity: From Structure to Function and Regulation

Philippe Belmont, Jean-Francois Constant, Martine Demeunynck

Journal:

Year:

2001

File:

PDF, 25 KB

2001

10

ChemInform Abstract: Synthesis and Study of 4-Hydroxymethyl-3-(alkylamino)acridines (I) as Models of a New Class of DNA-Intercalating—Alkylating Agents.

Franck Charmantray, Alain Duflos, Jean Lhomme, Martine Demeunynck

Journal:

Year:

2002

File:

PDF, 26 KB

2002

11

ChemInform Abstract: Tetrapyrido[3,2-a:2′,3′-c:3′′,2′′-h:2′′′,3′′′-j]acridine (tpac): A New Extended Polycyclic Bis-phenanthroline Ligand.

Martine Demeunynck, Cecile Moucheron, Andree Kirsch-De Mesmaker

Journal:

Year:

2002

File:

PDF, 26 KB

2002

12

ChemInform Abstract: New Route to Extended Angular Polyaza-heterocycles.

Franck Charmantray, Martine Demeunynck, Jean Lhomme, Alain Duflos

Journal:

Year:

2002

File:

PDF, 30 KB

2002

13

Regioselective Synthesis of Angular Nitrogen Polyheterocycles: Dipyrido[3,2-a:2′,3′-c]quinolino[2,3-h]phenazines.

Rodica Dinica, Franck Charmantray, Martine Demeunynck, Pascal Dumy

Journal:

Year:

2003

File:

PDF, 115 KB

2003

14

ChemInform Abstract: Swift and Efficient Synthesis of 4-Phenylquinazolines: Involvement of N-Heterocyclic Carbene in the Key Cyclization Step.

Julien Debray, Jean-Marc Leveque, Christian Philouze, Micheline Draye, Martine Demeunynck

Journal:

Year:

2010

File:

PDF, 28 KB

2010

15

ChemInform Abstract: Montmorillonite K-10 Catalyzed Cyclization of N-Ethoxycarbonyl-N′-arylguanidines: Access to Pyrimido[4,5-c]carbazole and Pyrimido[5,4-b]indole Derivatives.

Julien Debray, Walid Zeghida, Brigitte Baldeyrou, Christine Mahieu, Amelie Lansiaux, Martine Demeunynck

Journal:

Year:

2010

Language:

english

File:

PDF, 25 KB

english, 2010

16

Comparison of Different Strategies on DNA Chip Fabrication and DNA-Sensing: Optical and Electrochemical Approaches

Sabine Szunerits, Laurent Bouffier, Roberto Calemczuk, Bruno Corso, Martine Demeunynck, Emeline Descamps, Yann Defontaine, Jean-Bernard Fiche, Elodie Fortin, Thierry Livache, Pascal Mailley, André Rog

Journal:

Electroanalysis

Year:

2005

Language:

english

File:

PDF, 899 KB

english, 2005

17

Synthesis of tröger's base analogs derived from 3-aminoacridine and 10-aminobenzo[b][1,7]phenanthroline

Hervé Salez, Abderrahim Wardani, Martine Demeunynck, Arnaud Tatibouet, Jean Lhomme

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 219 KB

english, 1995

18

Dipyrido[3,2-a:2′,3′-c]quinolino[3,2-j]phenazine (dpqp-OH) – Synthesis, characterization and DNA interaction of the corresponding Ru(II) complex

Laurent Bouffier, Martine Demeunynck, Pascal Dumy, Cécile Moucheron, Andrée Kirsch-De Mesmaeker

Journal:

Inorganica Chimica Acta

Year:

2007

Language:

english

File:

PDF, 553 KB

english, 2007

19

Amino- and glycoconjugates of pyrido[4,3,2-kl]acridine. Synthesis, antitumor activity, and DNA binding

Laurent Bouffier, Brigitte Baldeyrou, Marie-Paule Hildebrand, Amélie Lansiaux, Marie-Hélène David-Cordonnier, Danièle Carrez, Alain Croisy, Olivier Renaudet, Pascal Dumy, Martine Demeunynck

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 1.25 MB

english, 2006

20

Photoreactive threading agent that specifically binds to abasic sites in DNA

Alain Martelli, Muriel Jourdan, Jean-François Constant, Martine Demeunynck, Pascal Dumy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 210 KB

english, 2006

21

Nitrobenzylcarbamate prodrugs of cytotoxic acridines for potential use with nitroreductase gene-directed enzyme prodrug therapy

Christian Asche, Pascal Dumy, Danièle Carrez, Alain Croisy, Martine Demeunynck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 249 KB

english, 2006

22

Synthesis of N-acridinyl-N′-alkylguanidines: Dramatic influence of amine to guanidine replacement on the physicochemical properties

Walid Zeghida, Julien Debray, Carine Michel, Anne Milet, Pascal Dumy, Martine Demeunynck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 460 KB

english, 2008

23

Functionalization of the A ring of pyridoacridine as a route toward greater structural diversity. Synthesis of an octacyclic analogue of eilatin

Laurent Bouffier, Rodica Dinica, Julien Debray, Pascal Dumy, Martine Demeunynck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 300 KB

english, 2009

24

Montmorillonite K-10 catalyzed cyclization of N-ethoxycarbonyl-N′-arylguanidines: Access to pyrimido[4,5-c]carbazole and pyrimido[5,4-b]indole derivatives

Julien Debray, Walid Zeghida, Brigitte Baldeyrou, Christine Mahieu, Amélie Lansiaux, Martine Demeunynck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 406 KB

english, 2010

25

Proflavine derivatives as fluorescent imaging agents of amyloid deposits

Dominique Garin, Fatima Oukhatar, Andrew B. Mahon, Andrew C. Try, Michel Dubois-Dauphin, Frank M. Laferla, Martine Demeunynck, Marcelle Moulin Sallanon, Sabine Chierici

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 665 KB

english, 2011

26

Unusual cellular uptake of cytotoxic 4-hydroxymethyl-3-aminoacridine

Paul Peixoto, Walid Zeghida, Danièle Carrez, Ting-Di Wu, Nicole Wattez, Alain Croisy, Martine Demeunynck, Jean-Luc Guerquin-Kern, Amélie Lansiaux

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 975 KB

english, 2009

27

The diastereoisomeric forms of a mononuclear Ru(II) complex bearing a bis-phenanthroline Tröger’s base

Carole Bresson, Michel Luhmer, Martine Demeunynck, Andrée Kirsch-De Mesmaeker, Frédéric Pierard

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 316 KB

english, 2004

28

Synthesis of purine-acridine hybrid molecules related to artificial endonucleases

Abdellatif Fkyerat, Martine Demeunynck, Jean-François Constant, Jean Lhomme

Journal:

Year:

1993

Language:

english

File:

PDF, 1.08 MB

english, 1993

29

Synthesis of N-acridinyl and N-quinolinyl derivatives of radioprotective amino-thiols

Patrice Demonchaux, Ali Laayoun, Martine Demeunynck, Jean Lhomme

Journal:

Year:

1989

Language:

english

File:

PDF, 763 KB

english, 1989

30

Design of site specific DNA damaging agents for generation of multiply damaged sites

Alain Martelli, Jean-Francois Constant, Martine Demeunynck, Jean Lhomme, Pascal Dumy

Journal:

Year:

2002

Language:

english

File:

PDF, 280 KB

english, 2002

31

Reaction of 3-amino-acridine with formaldehyde in acidic medium: Influence of the stoechiometry on the reaction products

Arnaud Tatibouët, Noémie Fixler, Martine Demeunynck, Jean Lhomme

Journal:

Year:

1997

Language:

english

File:

PDF, 471 KB

english, 1997

32

Tetrapyrido[3,2-a:2′,3′-c:3″,2″-h:2‴,3‴-j]acridine (tpac): a new extended polycyclic bis-phenanthroline ligand

Martine Demeunynck, Cécile Moucheron, Andrée Kirsch-De Mesmaeker

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 156 KB

english, 2002

33

1-acetoxy-4-hydroxyimino-1,4-dihydroquinoline, a reactive intermediate derived from the potent carcinogen 4-nitroquinoline N-oxide

Martine Demeunynck, Marie France Lhomme, Jean Lhomme

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 220 KB

english, 1981

34

Regioselective synthesis of angular nitrogen polyheterocycles: dipyrido[3,2-a:2′,3′-c]quinolino[2,3-h]phenazines

Rodica Dinica, Franck Charmantray, Martine Demeunynck, Pascal Dumy

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 89 KB

english, 2002

35

The abasic site as a target for generation of locally multiply damaged sites

Alain Martelli, Nathalie Berthet, Jean-François Constant, Martine Demeunynck, Jean Lhomme

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 784 KB

english, 2000

36

Diaminopurine-acridine heterodimers for specific recognition of abasic site containing DNA. Influence on the biological activity of the position of the linker on the purine ring

Karine Alarcon, Martine Demeunynck, Jean Lhomme, Danièle Carrez, Alain Croisy

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 203 KB

english, 2001

37

Introduction of a nitroxide group on position 2 of 9-phenoxyacridine: Easy access to spin labelled DNA-binding conjugates

Philippe Belmont, Christian Chapelle, Martine Demeunynck, Josette Michon, Pierre Michon, Jean Lhomme

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 405 KB

english, 1998

38

Synthesis of an imidazo[1,2-e]purine-acridine heterodimer for targeting abasic sites in DNA

Philippe Belmont, Karine Alarcon, Martine Demeunynck, Jean Lhomme

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 267 KB

english, 1999

39

Synthesis and study of a new adenine–acridine tandem, inhibitor of exonuclease III

Philippe Belmont, Martine Demeunynck, Jean-François Constant, Jean Lhomme

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 168 KB

english, 2000

40

Molecular modeling study of DNA abasic sites

Leila Ayadi, Damien Forget, Alain Martelli, Jean-François Constant, Martine Demeunynck, Christian Coulombeau

Journal:

Theoretical Chemistry Accounts: Theory, Computation, and Modeling (Theoretica Chimica Acta)

Year:

2000

Language:

english

File:

PDF, 209 KB

english, 2000

41

3,4-Dihydro-1H-[1,3]oxazino[4,5-c]acridines as a new family of cytotoxic drugs

Myriam Ouberai, Christian Asche, Danièle Carrez, Alain Croisy, Pascal Dumy, Martine Demeunynck

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 115 KB

english, 2006

42

2-Amino-6-(1,2,4-triazol-4-yl)-purine: a useful intermediate in the synthesis of 9-alkylguanines

Karine Alarcon, Alain Martelli, Martine Demeunynck, Jean Lhomme

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 133 KB

english, 2000

43

Synthesis and DNA interaction of a mixed proflavine–phenanthroline Tröger base

Brigitte Baldeyrou, Christelle Tardy, Christian Bailly, Pierre Colson, Claude Houssier, Franck Charmantray, Martine Demeunynck

Journal:

European Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 273 KB

english, 2002

44

Potentiation of BCNU Cytotoxicity by Molecules Targeting Abasic Lesions in DNA

Karine Alarcon, Martine Demeunynck, Jean Lhomme, Danièle Carrez, Alain Croisy

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 342 KB

english, 2001

45

Synthesis and study of an acridine substituted Tröger’s base: preferential binding of the (–)-isomer to B-DNA

Tatibouët, Arnaud, Demeunynck, Martine, Andraud, Chantal, Collet, André, Lhomme, Jean

Journal:

Chemical Communications

Year:

1999

Language:

english

File:

PDF, 69 KB

english, 1999

46

Preparation and properties of 4-nitrosoquinolines

Martine Demeunynck, Najat Tohme, Marie-France Lhomme, Jean Lhomme

Journal:

Journal of Heterocyclic Chemistry

Year:

1984

File:

PDF, 216 KB

1984

47

Catalyst-free synthesis of quinazolin-4-ones from (hetero)aryl-guanidines: application to the synthesis of pyrazolo[4,3-f]quinazolin-9-ones, a new family of DYRK1A inhibitors

Debray, Julien, Bonte, Simon, Lozach, Olivier, Meijer, Laurent, Demeunynck, Martine

Journal:

Molecular Diversity

Year:

2012

Language:

english

File:

PDF, 1.13 MB

english, 2012

48

Enantiospecific Recognition of DNA Sequences by a Proflavine Tröger Base

Christian Bailly, William Laine, Martine Demeunynck, Jean Lhomme

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 202 KB

english, 2000

49

A phenanthrolinoquinomethane: synthesis and study of precursors

Fixler, Noemie, Salez, Herv�, Demeunynck, Martine, Lhomme, Jean

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1995

Language:

english

File:

PDF, 603 KB

english, 1995

50

Synthesis and evaluation of fused bispyrimidinoacridines as novel pentacyclic analogues of quadruplex-binder BRACO-19

Debray, Julien, Zeghida, Walid, Jourdan, Muriel, Monchaud, David, Dheu-Andries, Marie-Louise, Dumy, Pascal, Teulade-Fichou, Marie-Paule, Demeunynck, Martine

Journal:

Organic & Biomolecular Chemistry

Year:

2009

Language:

english

File:

PDF, 426 KB

english, 2009